{"id":799,"date":"2026-02-20T12:15:38","date_gmt":"2026-02-20T17:15:38","guid":{"rendered":"https:\/\/staging.jinarc.ca\/?page_id=799"},"modified":"2026-03-25T13:03:57","modified_gmt":"2026-03-25T17:03:57","slug":"mode-daction","status":"publish","type":"page","link":"https:\/\/hcp.jinarc.ca\/fr\/mode-daction\/","title":{"rendered":"Mode d&rsquo;action"},"content":{"rendered":"<div class=\"et_pb_section_0 et_pb_section et_section_regular et_flex_section\">\n<div class=\"et_pb_row_0 et_pb_row et_flex_row\">\n<div class=\"et_pb_column_0 et_pb_column et-last-child et_flex_column et_pb_css_mix_blend_mode_passthrough et_flex_column_24_24 et_flex_column_24_24_tablet et_flex_column_24_24_phone\">\n<div class=\"et_pb_text_0 et_pb_text et_pb_bg_layout_light et_pb_module et_flex_module\"><div class=\"et_pb_text_inner\"><h3><sup>Pr<\/sup>JINARC<sup>MD<\/sup> : un antagoniste s\u00e9lectif des r\u00e9cepteurs V<sub>2<\/sub> de la vasopressine ayant deux modes d\u2019action (donn\u00e9es in vitro)<sup>1,2\u2020<\/sup><\/h3>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n<div class=\"et_pb_row_1 et_pb_row et_flex_row\">\n<div class=\"et_pb_column_1 et_pb_column et_flex_column et_pb_css_mix_blend_mode_passthrough et_flex_column_16_24 et_flex_column_16_24_tablet et_flex_column_24_24_phone\">\n<div class=\"et_pb_video_0 et_pb_video et_pb_module et_block_module\"><div class=\"et_pb_video_box\"><video controls><source type=\"video\/mp4\" src=\"https:\/\/hcp.jinarc.ca\/wp-content\/uploads\/2026\/02\/12817_Jinarc-MOA-Video-PAAB_FR_.mp4\" \/><source type=\"video\/webm\" src=\"https:\/\/hcp.jinarc.ca\/wp-content\/uploads\/2026\/02\/12817_Jinarc-MOA-Video-PAAB_FR.webm\" \/><\/video><\/div><div class=\"et_pb_video_overlay\" style=\"background-image:url(https:\/\/hcp.jinarc.ca\/wp-content\/uploads\/2026\/01\/MOA-Placeholder.png)\"><div class=\"et_pb_video_overlay_hover\"><a class=\"et_pb_video_play\" href=\"#\"><\/a><\/div><\/div><\/div>\n<\/div>\n\n<div class=\"et_pb_column_2 et_pb_column et-last-child et_flex_column et_pb_css_mix_blend_mode_passthrough et_flex_column_8_24 et_flex_column_8_24_tablet et_flex_column_24_24_phone scroll-col\">\n<div class=\"et_pb_group_0 et_pb_group et-last-child et_pb_module et_flex_group et_pb_css_mix_blend_mode_passthrough scroll-group\">\n<div class=\"et_pb_text_1 et_pb_text et_pb_bg_layout_light et_pb_module et_flex_module\"><div class=\"et_pb_text_inner\"><h3>Transcription<\/h3>\n<p><em>Mode d\u2019action de JINARC (tolvaptan). <\/em><\/p>\n<p><em>JINARC est le premier traitement indiqu\u00e9 pour ralentir la progression de l\u2019hypertrophie des reins chez les patients atteints de la maladie polykystique r\u00e9nale autosomique dominante (la MPRAD), et aussi le d\u00e9clin de la fonction r\u00e9nale. JINARC, un antagoniste s\u00e9lectif des r\u00e9cepteurs V<sub>2<\/sub> de la vasopressine inhibe la liaison de la vasopressine au r\u00e9cepteur V<sub>2<\/sub> dans les cellules de l\u2019\u00e9pith\u00e9lium tubulaire du rein. <\/em><\/p>\n<p style=\"font-weight: 400;\"><em>La diminution de la liaison de la vasopressine au r\u00e9cepteur V<sub>2<\/sub> a pour effet d\u2019abaisser l\u2019activit\u00e9 de l\u2019ad\u00e9nylate cyclase. Elle r\u00e9duit ainsi les taux intracellulaires d\u2019AMP cyclique. Des analyses in vitro ont r\u00e9v\u00e9l\u00e9 qu\u2019en r\u00e9duisant le taux d\u2019AMP cyclique dans ces cellules, on diminue la prolif\u00e9ration cellulaire et la s\u00e9cr\u00e9tion de liquide dans la lumi\u00e8re du kyste. On assiste, en retour, \u00e0 une inhibition de la croissance kystique stimul\u00e9e par l\u2019arginine-vasopressine (AVP).<\/em><\/p>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<div class=\"et_pb_row_2 et_pb_row et_flex_row\">\n<div class=\"et_pb_column_3 et_pb_column et-last-child et_flex_column et_pb_css_mix_blend_mode_passthrough et_flex_column_24_24 et_flex_column_24_24_tablet et_flex_column_24_24_phone\">\n<div class=\"et_pb_code_0 et_pb_code et_pb_module\"><div class=\"et_pb_code_inner\"><script>\n(function() {\n  function syncTranscriptHeight() {\n    var videoCol = document.querySelector('.et_pb_row_1 .et_pb_column_1');\n    var scrollGroup = document.querySelector('.et_pb_row_1 .et_pb_column_2.scroll-col .scroll-group');\n    if (!videoCol || !scrollGroup) return;\n    var h = videoCol.getBoundingClientRect().height;\n    scrollGroup.style.maxHeight = h + 'px';\n  }\n  window.addEventListener('load', syncTranscriptHeight);\n  window.addEventListener('resize', syncTranscriptHeight);\n})();\n<\/script><\/div><\/div>\n<\/div>\n<\/div>\n\n<div class=\"et_pb_row_3 et_pb_row et_flex_row\">\n<div class=\"et_pb_column_4 et_pb_column et-last-child et_flex_column et_pb_css_mix_blend_mode_passthrough et_flex_column_24_24 et_flex_column_24_24_tablet et_flex_column_24_24_phone\">\n<div class=\"et_pb_text_2 et_pb_text et_pb_bg_layout_light et_pb_module et_flex_module\"><div class=\"et_pb_text_inner\"><h3>L\u2019affinit\u00e9 de JINARC pour le r\u00e9cepteur V<sub>2<\/sub> est 1,8 fois sup\u00e9rieure \u00e0 celle de l\u2019AVP native.<\/h3>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n<div class=\"et_pb_row_4 et_pb_row et_flex_row\">\n<div class=\"et_pb_column_5 et_pb_column et-last-child et_flex_column et_pb_css_mix_blend_mode_passthrough et_flex_column_24_24 et_flex_column_24_24_tablet et_flex_column_24_24_phone\">\n<div class=\"et_pb_text_3 et_pb_text et_pb_bg_layout_light et_pb_module et_flex_module\"><div class=\"et_pb_text_inner\"><p>\u2020 La pertinence clinique est inconnue.<\/p>\n<\/div><\/div>\n\n<div class=\"et_pb_row_5 et_pb_row et_pb_row_nested et_flex_row\">\n<div class=\"et_pb_column_6 et_pb_column et-last-child et_flex_column et_pb_css_mix_blend_mode_passthrough et_flex_column_24_24 et_flex_column_24_24_tablet et_flex_column_24_24_phone\">\n<div class=\"et_pb_code_1 et_pb_code et_pb_module\"><div class=\"et_pb_code_inner\"><a href=\"#safety\" style=\"display:none;\">Safety<\/a><\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-799","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/hcp.jinarc.ca\/fr\/wp-json\/wp\/v2\/pages\/799","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hcp.jinarc.ca\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/hcp.jinarc.ca\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/hcp.jinarc.ca\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/hcp.jinarc.ca\/fr\/wp-json\/wp\/v2\/comments?post=799"}],"version-history":[{"count":18,"href":"https:\/\/hcp.jinarc.ca\/fr\/wp-json\/wp\/v2\/pages\/799\/revisions"}],"predecessor-version":[{"id":1372,"href":"https:\/\/hcp.jinarc.ca\/fr\/wp-json\/wp\/v2\/pages\/799\/revisions\/1372"}],"wp:attachment":[{"href":"https:\/\/hcp.jinarc.ca\/fr\/wp-json\/wp\/v2\/media?parent=799"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}